Constitutive translation of human α-synuclein is mediated by the 5′-untranslated region
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چکیده
منابع مشابه
Constitutive translation of human α-synuclein is mediated by the 5′-untranslated region
Genetic and biochemical studies have established a central role for α-synuclein (SNCA) accumulation in the pathogenesis of Parkinson's disease. Uncovering and subsequently interfering with physiological mechanisms that control SNCA expression is one approach to limit disease progression. To this end, the long and GC-rich 5'-untranslated region (UTR) of SNCA, which is predicted to fold into stab...
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Genetic and biochemical studies have established a central role for a-synuclein (SNCA) accumulation in the pathogenesis of Parkinson’s disease. Uncovering and subsequently interfering with physiological mechanisms that control SNCA expression is one approach to limit disease progression. To this end, the long and GC-rich 50-untranslated region (UTR) of SNCA, which is predicted to fold into stab...
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ژورنال
عنوان ژورنال: Open Biology
سال: 2016
ISSN: 2046-2441
DOI: 10.1098/rsob.160022